TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-

Product Name: TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-
CAS No.: 186020-66-6
Chemical Name: TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-
Synonyms: HO-PEG3-tBu;OH-PEG3-TBA;HO-PEG3-COOtBu;OH-PEG3-(CH2)2-Boc;HO-PEG3-CH2CH2COOtBu;OH-PEG3-CH2CH2COOtBu;HO-PEG3-t-Butyl ester;Hydroxy-PEG4-t-butyles;Hydroxy-PEG3-(CH2)2-Boc;12-HYDROXY-4 7 10-TRIOXA-
CBNumber: CB1497771
Molecular Formula: C13H26O6
Formula Weight: 278.34
MOL File: 186020-66-6.mol

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TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- Property

Boiling point:: 365.8±27.0 °C(Predicted)
Density: 1.052 g/mL at 20 °C (lit.)
refractive index: n20/D 1.446
storage temp.: Inert atmosphere,Room Temperature
solubility: Soluble in DMSO
form: clear liquid
pka: 14.36±0.10(Predicted)
color: Colorless to Light yellow to Light orange
BRN: 7638988
CAS DataBase Reference: 186020-66-6

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Safety

WGK Germany: 3
F: 10
HS Code: 2918999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 83062
Product name: tert-Butyl 12-hydroxy-4,7,10-trioxadodecanoate
Purity: ≥97.0%(GC)
Packaging: 5G
Price: $138.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: 83062
Product name: tert-Butyl 12-hydroxy-4,7,10-trioxadodecanoate
Purity: ≥97.0%(GC)
Packaging: 1g
Price: $78.2
Updated: 2023/06/20

TCI Chemical

Product number: B5587
Product name: tert-Butyl 12-Hydroxy-4,7,10-trioxadodecanoate
Purity: >97.0%(GC)
Packaging: 1g
Price: $68
Updated: 2024/03/01

TCI Chemical

Product number: B5587
Product name: tert-Butyl 12-Hydroxy-4,7,10-trioxadodecanoate
Purity: >97.0%(GC)
Packaging: 5g
Price: $272
Updated: 2024/03/01

TRC

Product number: B809908
Product name: tert-Butyl 12-hydroxy-4,7,10-trioxadodecanoate
Packaging: 100mg
Price: $60
Updated: 2021/12/16

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TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- Chemical Properties,Usage,Production

Description

Hydroxy-PEG3-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Biological Activity

Tert-Butyl-12-hydroxy-4,7,10-trioxadodecanoate is an ADC linker for the synthesis of antibody drug conjugates (ADC), it is derived from patent WO2004008101A2 (compound 196). It can also be used as a PROTAC linker for PROTAC synthesis. .

in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Non-cleavable

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PEGs

Alkyl/ether

TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- Preparation Products And Raw materials

Raw materials

Preparation Products

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TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- Suppliers

Americas 1 China 110 Europe 1 India 2 Japan 1 Switzerland 1 United Kingdom 1 United States 18 Global 135

ChemPep, Inc.

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Aladdin Scientific

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View Lastest Price from TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Hydroxy-PEG3-t-butyl ester 186020-66-6
Price: US $0.00/g
Min. Order: 25g
Purity: >98.00%
Supply Ability: 25g
Release date: 2024-03-25

Career Henan Chemical Co

Product: TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- 186020-66-6
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-07-04

186020-66-6, TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-Related Search:

Hydroxy-PEG4-t-butyl ester Bis-PEG6-t-butyl ester tert-Butyl 3-[2-(2-{2-[2-(2-tert-butoxycarbonylethoxy)ethoxy]ethoxy}ethoxy) -ethoxy]propionate alpha-Azido-omega-hydroxy octa(ethylene glycol) PENTAETHYLENE GLYCOL (R)-N-(3,6,9,12-Tetraoxatridecyl)-alpha-lipoamide alpha, oMega-Dipropionic acid hexaethylene glycol Z-15-aMino-4,7,10,13-tetraoxapentadecacanoic acid FMoc-NH-8(ethylene glycol)-acetic acid FMOC-18-AMINO-4,7,10,13,16-PENTAOXAOCTADECANOIC ACID HEPTAETHYLENE GLYCOL MPEG7-CH2CH2COOH Amino-PEG2-acid 2-[2-[2-[2-(BENZYLOXY)ETHOXY]ETHOXY]ETHOXY]ETHANOL Propargyl-PEG5-alcohol Triethylene Glycol Mono(2-propynyl) Ether Ethanol, 2-[2-(2-hydroxyethoxy)ethoxy]-, 1-(4-Methylbenzenesulfonate) HEPTAETHYLENE GLYCOL Monobenzyl ether

HO-PEG3-COOtBu

Hydroxy-PEG3-(CH2)2-Boc

OH-PEG3-CH2CH2COOtBu

OH-PEG3-TBA

HO-PEG3-t-Butyl ester

tert-Butyl 3-(2-(2-(2-hydroxyethoxy)

12-HYDROXY-4 7 10-TRIOXA-

Hydroxy-PEG4-t-butyles

TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-

HO-PEG3-tBu

HO-PEG3-CH2CH2COOtBu

3-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]propionic acid tert-butyl ester

tert-Butyl 12-hydroxy-4,7,10-trioxadodecanoate >=97.0% (GC)

Hydroxy-PEG4-t-butylester

Propanoic acid, 3-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-, 1,1-dimethylethyl ester

HO(CH2CH2O)3CH2CH2COOT-BU

tert-Butyl PEG3 propanoate

12-Hydroxy-4,7,10-trioxadodecanoic Acid tert-Butyl Ester

HO-PEG3-CH2CH2COOtBu/Propanoic acid, 3-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-, 1,1-dimethylethyl ester

OH-PEG3-(CH2)2-Boc

186020-66-6

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